Neobiotic may be available in the countries listed below.
In some countries, this medicine may only be approved for veterinary use.
Neomycin sulfate (a derivative of Neomycin) is reported as an ingredient of Neobiotic in the following countries:
International Drug Name Search
Generic Name: drotrecogin alfa (droe tre KOE gin AL fa)
Brand Names: Xigris
Drotrecogin alfa is a form of human protein (Protein C).
Drotrecogin alfa is used to treat sepsis in patients who have a high risk of death due to multi-system organ failure.
Drotrecogin alfa was withdrawn from the U.S. market in October 2011.
Drotrecogin alfa may also be used for purposes not listed in this medication guide.
You should not receive this medication if you have active internal bleeding, brain cancer, tumor, or bleeding in the brain. You should also not receive drotrecogin alfa if you have had brain or spine surgery or a head injury in the past 2 months, or if you have had a stroke within the past 3 months.
Before receiving drotrecogin alfa, tell your doctor if you have severe liver disease, a bleeding or blood clotting disorder, if you have recently had stomach or intestinal bleeding, or have recently taken aspirin, a blood-thinner, or medications to treat or prevent blood clots.
active internal bleeding;
brain cancer, tumor, or bleeding in the brain;
if you have had brain or spine surgery or a head injury in the past 2 months; or
if you have had a stroke within the past 3 months.
Before you receive drotrecogin alfa, tell your doctor if you are allergic to any drugs, or if you have:
severe liver disease;
a bleeding or blood clotting disorder;
if you have had stomach or intestinal bleeding within the past 6 weeks;
if you have received treatment for blood clots within the past 3 days; or
if you have taken aspirin or a blood thinner (such as warfarin, Coumadin), or anti-platelet medication (dipyridamole, Persantine, clopidogrel, Plavix) within the past 7 days.
If you have any of these conditions, you may need a dose adjustment or special tests to safely receive drotrecogin alfa.
Drotrecogin alfa is given as an injection through a needle placed into a vein. You will most likely receive this injection in a hospital setting.
Drotrecogin alfa must be given slowly through an IV infusion, and can take up to 4 days to complete.
Since drotrecogin alfa is given as needed by a healthcare professional, it is not likely that you will miss a dose.
Overdose symptoms may include unusual bleeding, or any bleeding that won't stop.
Follow your doctor's instructions about any restrictions on food, beverages, or activity while you are receiving drotrecogin alfa..
blood in your urine or stools;
coughing up blood or vomit that looks like coffee grounds;
bleeding from any incision or injection in your skin; or
any bleeding that won't stop.
This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.
Usual Adult Dose for Sepsis:
Drotrecogin alfa was voluntarily withdrawn from the market by the manufacturer in October, 2011 due to failure to show a survival benefit for patients with severe sepsis and septic shock. The following dosage information applies to when the drug was available in the U.S.
24 mcg/kg/hr by intravenous infusion for 96 hours
Usual Pediatric Dose for Sepsis:
Drotrecogin alfa was voluntarily withdrawn from the market by the manufacturer in October, 2011 due to failure to show a survival benefit for patients with severe sepsis and septic shock. The following dosage information applies to when the drug was available in the U.S.
Multiple study data:
0 to 18 years: 24 mcg/kg/hr by intravenous infusion for 96 hours.
Before receiving drotrecogin alfa, tell your doctor if you have recently received any of the following medications prevent blood clots:
alteplase (Activase);
anistreplase (Eminase);
clopidogrel (Plavix);
dipyridamole (Persantine);
streptokinase (Kabikinase, Streptase);
ticlopidine (Ticlid);
urokinase (Abbokinase).
This list is not complete and there may be other drugs that can interact with drotrecogin alfa. Tell your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start a new medication without telling your doctor.
See also: drotrecogin alfa side effects (in more detail)
NeoCitran Hustenlöser may be available in the countries listed below.
Acetylcysteine is reported as an ingredient of NeoCitran Hustenlöser in the following countries:
International Drug Name Search
Sacvercot may be available in the countries listed below.
Probucol is reported as an ingredient of Sacvercot in the following countries:
International Drug Name Search
