oxtriphylline

Generic Name: oxtriphylline (ox TRYE fi lin)

Brand Names: Choledyl, Choledyl SA

What is oxtriphylline?

Oxtriphylline is a bronchodilator. Oxtriphylline works in several ways: it relaxes muscles in your lungs and chest to allow more air in, decreases the sensitivity of your lungs to allergens and other substances that cause inflammation, and increases the contractions of your diaphragm to draw more air into the lungs.

Oxtriphylline is used to treat the symptoms of asthma, bronchitis, and emphysema.

Oxtriphylline may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about oxtriphylline?

Do not crush or chew any extended-release formulation of oxtriphylline. Swallow the medication whole. It is specially formulated to release slowly in your body. If you do not know whether your medication is an extended-release formulation, ask your pharmacist.

Call your doctor right away if you experience nausea, vomiting, insomnia, restlessness, seizures, an increased heart rate, or a headache. These could be signs of too much oxtriphylline in your blood.

Do not start or stop smoking without your doctor's knowledge. Smoking may affect your dosage.

Do not take more of this medicine than is prescribed without consulting your doctor. Seek medical attention if you are having increasing difficulty breathing.

Who should not take oxtriphylline?

Before taking this medication, tell your doctor if you have

• 
  

  a stomach ulcer;

  
  


• 
  

  seizures;

  
  


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  high blood pressure, a heart condition, or any type of heart disease;

  
  


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  fluid in your lungs;

  
  


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  a thyroid condition;

  
  


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  liver disease; or

  
  


• 
  

  kidney disease.

  
  

You may not be able to take oxtriphylline, or you may require a lower dose or special monitoring during treatment if you have any of the conditions listed above.

Oxtriphylline is in the FDA pregnancy category C. This means that it is not known whether oxtriphylline will harm an unborn baby. Do not take this medication without first talking to your doctor if you are pregnant. Oxtriphylline passes into breast milk and could affect a nursing baby. Do not take oxtriphylline without first talking to your doctor if you are breast-feeding a baby. If you are over 60 years of age, you may be more likely to experience side effects from oxtriphylline. You may require a lower dose of this medication.

How should I take oxtriphylline?

Take oxtriphylline exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.

Take each dose with a full glass of water. You can take oxtriphylline with food to lessen stomach upset.

Take your doses at the same time every day to keep a constant level of oxtriphylline in your blood.

Do not crush or chew any extended-release formulation of oxtriphylline. Swallow the medication whole. It is specially formulated to release slowly in your body. If you do not know whether your medication is an extended-release formulation, ask your pharmacist. Shake the liquid forms of this medication well before use. To ensure that you get a correct dose, measure the liquid with a dose-measuring cup or spoon, not a regular tablespoon. If a spoon or cup is not provided with the medication and you do not have one, ask your pharmacist where you can get one.

Do not switch to another brand or a generic form of oxtriphylline without the approval of your doctor.

Store oxtriphylline at room temperature away from moisture and heat.

See also: Oxtriphylline dosage (in more detail)

What happens if I miss a dose?

Take the missed dose as soon as you remember. However, if it is almost time for your next regularly scheduled dose, skip the missed dose and take the next one as directed. Do not take a double dose of this medication.

What happens if I overdose?

Seek emergency medical attention.

Symptoms of a oxtriphylline overdose include nausea, vomiting, headache, insomnia, tremor (shaking hands or twitching,), restlessness, seizures, and irregular heartbeats.

What should I avoid while taking oxtriphylline?

Use caution when driving, operating machinery, or performing other hazardous activities. Oxtriphylline may cause dizziness or drowsiness. If you experience dizziness or drowsiness, avoid these activities.

Do not start or stop smoking without the approval of your doctor. Smoking changes the way your body uses oxtriphylline, and you may need a dose adjustment.

Avoid changing your dose or changing the time of your daily doses.

Do not change the brand, generic form, or formulation (tablet, capsule, liquid) of oxtriphylline that you are taking without the approval of your doctor. Different brands or formulations may require different dosages.

Avoid eating excessive amounts of grilled or char-broiled foods. Doing so may also change the dose of oxtriphylline that you need.

Avoid caffeinated beverages such as coffee, tea, and cola. Oxtriphylline is related chemically to caffeine, and you may experience some side effects if you consume too much caffeine.

Oxtriphylline side effects

If you experience any of the following serious side effects, stop taking oxtriphylline and seek emergency medical attention:

• 
  

  an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives);

  
  


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  seizures;

  
  


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  increased or irregular heartbeats; or

  
  


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  severe nausea or vomiting.

  
  

Other, less serious side effects may occur although they are not common at appropriate doses. Continue to take oxtriphylline and talk to your doctor if you experience

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  slight nausea, decreased appetite, or weight loss;

  
  


• 
  

  restlessness, tremor, or insomnia; or

  
  


• 
  

  headache, lightheadedness, or dizziness.

  
  

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

Oxtriphylline Dosing Information

Usual Adult Dose for Asthma -- Maintenance:

4.7 mg/kg orally every 8 hours.

Usual Pediatric Dose for Asthma -- Maintenance:

Child 1-9 years: 6.2 mg/kg orally every 6 hours.

Child 9-16 years: 4.7 mg/kg orally every 6 hours.

What other drugs will affect oxtriphylline?

Oxtriphylline interacts with many other drugs. Tell your doctor and pharmacist about all other medications that you are taking, including herbal remedies, vitamins, and other nonprescription items.

The following drugs may increase the levels of oxtriphylline in your blood, leading to dangerous side effects:

• 
  

  alcohol;

  
  


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  cimetidine (Tagamet, Tagamet HB);

  
  


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  fluoroquinolone antibiotics such as enoxacin (Penetrex), lomefloxacin (Maxaquin), ciprofloxacin (Cipro), norfloxacin (Noroxin), and ofloxacin (Floxin);

  
  


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  clarithromycin (Biaxin) and erythromycin (Ery-Tab, E.E.S., E-Mycin, others);

  
  


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  disulfiram (Antabuse);

  
  


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  estrogens (Ogen, Premarin, and many other types);

  
  


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  fluvoxamine (Luvox);

  
  


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  methotrexate (Folex, Rheumatrex);

  
  


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  mexiletine (Mexitil) and propafenone (Rythmol);

  
  


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  propranolol (Inderal);

  
  


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  tacrine (Cognex);

  
  


• 
  

  ticlopidine (Ticlid); and

  
  


• 
  

  verapamil (Verelan, Calan, Isoptin).

  
  

The following drugs may decrease theophylline levels in your blood, leading to poor asthma control:

• 
  

  aminoglutethimide (Cytadren),

  
  


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  carbamazepine (Tegretol),

  
  


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  isoproterenol (Isuprel),

  
  


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  moricizine (Ethmozine),

  
  


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  phenobarbital (Luminal, Solfoton),

  
  


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  phenytoin (Dilantin),

  
  


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  rifampin (Rifadin), and

  
  


• 
  

  sucralfate (Carafate).

  
  

Drugs other than those listed here may also interact with oxtriphylline or affect your condition. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines.

More oxtriphylline resources

• Oxtriphylline Side Effects (in more detail)
• Oxtriphylline Dosage
• Oxtriphylline Use in Pregnancy & Breastfeeding
• Oxtriphylline Drug Interactions
• Oxtriphylline Support Group
• 0 Reviews for Oxtriphylline - Add your own review/rating

Compare oxtriphylline with other medications

• Asthma, Maintenance

Where can I get more information?

• Your pharmacist has additional information about oxtriphylline written for health professionals that you may read.

What does my medication look like?

Many different formulations of oxtriphylline are available with a prescription under the brand name Choledyl and generically. Regular-release tablets, sustained-release tablets, a syrup, and an elixir are all available. Ask your pharmacist any questions you have about this medication, especially if it is new to you.

See also: oxtriphylline side effects (in more detail)

Guaiacalcium Complex

Guaiacalcium Complex may be available in the countries listed below.

Ingredient matches for Guaiacalcium Complex

Dropropizine

Dropropizine is reported as an ingredient of Guaiacalcium Complex in the following countries:

• Italy

Sulfogaiacol

Sulfogaiacol is reported as an ingredient of Guaiacalcium Complex in the following countries:

• Italy

International Drug Name Search

Diclofenac/Misoprostol

Pronunciation: dye-KLOE-fen-ak/MYE-soe-PROST-ol
Generic Name: Diclofenac/Misoprostol
Brand Name: Arthrotec

Diclofenac/Misoprostol is contraindicated in pregnant women because the misoprostol component can cause abortion. Misoprostol has been shown to cause the uterus to tear in pregnant women if it is used to induce labor or to cause an abortion after the first trimester of pregnancy. Diclofenac/Misoprostol should only be given to women of childbearing age when nonsteroidal anti-inflammatory drug (NSAID) therapy is required and the patient is at high risk of developing stomach ulcers or complications from stomach ulcers. Diclofenac/Misoprostol may be prescribed only if the patient has had a negative pregnancy test within 2 weeks before beginning therapy; is capable of using hormonal birth control (eg, birth control pills); has received oral and written warnings of the serious side effects associated with misoprostol, the risk of failed birth control, and the danger to women of childbearing age who take Diclofenac/Misoprostol by mistake; and will begin taking Diclofenac/Misoprostol only the second or third day of the next normal menstrual period. Diclofenac/Misoprostol is to be used only by the patient for whom it is prescribed. Do not share it with others.

Diclofenac/Misoprostol contains a nonsteroidal anti-inflammatory drug (NSAID). It may cause an increased risk of serious, and sometimes fatal, heart and blood vessel problems (eg, a heart attack, stroke). The risk may be greater if you already have heart problems or if you take Diclofenac/Misoprostol for a long time. Do not use Diclofenac/Misoprostol right before or after bypass heart surgery.

Diclofenac/Misoprostol may cause an increased risk of serious and sometimes fatal stomach ulcers and bleeding. Elderly patients may be at greater risk. This may occur without warning signs.

Diclofenac/Misoprostol is used for:

Treating joint swelling, pain, and stiffness caused by osteoarthritis or rheumatoid arthritis in patients who are at a high risk of developing NSAID-induced ulcers or their complications. It may also be used for other conditions as determined by your doctor.

Diclofenac/Misoprostol is an NSAID and prostaglandin analog combination. The prostaglandin maintains prostaglandin activity needed to protect the lining of the stomach and reduce acid secretion, reducing the risk of ulcers. The NSAID decreases prostaglandins that cause pain and inflammation, relieving joint pain.

Do NOT use Diclofenac/Misoprostol if:

• you are allergic to any ingredient in Diclofenac/Misoprostol or other prostaglandins


• you are pregnant


• you have had a severe allergic reaction (eg, severe rash, hives, trouble breathing, growths in the nose, dizziness) to aspirin or another NSAID (eg, ibuprofen, naproxen, celecoxib)


• you have recently had or will be having bypass heart surgery


• you have liver problems (eg, hepatic porphyria)

Contact your doctor or health care provider right away if any of these apply to you.

Before using Diclofenac/Misoprostol:

Some medical conditions may interact with Diclofenac/Misoprostol. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you have a history of kidney or liver problems, diabetes, or stomach or bowel problems (eg, bleeding, perforation, ulcers)


• if you have a history of swelling or fluid buildup, seizures, lupus, asthma, or growths in the nose (nasal polyps)


• if you have high blood pressure, blood problems (eg, anemia, porphyria, low blood platelets), bleeding or clotting problems, heart problems (eg, heart failure), blood vessel disease, inflammatory bowel disease, seizures, or if you are at risk of any of these diseases


• if you are dehydrated, if you drink alcohol or have a history of alcohol abuse, or if you smoke

Some MEDICINES MAY INTERACT with Diclofenac/Misoprostol. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Anticoagulants (eg, warfarin), aspirin, clopidogrel, corticosteroids (eg, prednisone), direct factor Xa inhibitors (eg, rivaroxaban), heparin, prasugrel, or selective serotonin reuptake inhibitors (SSRIs) (eg, citalopram, paroxetine) because the risk of bleeding may be increased


• Oral diabetic medicines (eg, glipizide) or insulin because the risk of high or low blood sugar may be increased


• Azole antifungals (eg, itraconazole, voriconazole), bisphosphonates (eg, risedronate), or probenecid because they may increase the risk of Diclofenac/Misoprostol's side effects


• Rifamycins (eg, rifampin) because they may decrease Diclofenac/Misoprostol's effectiveness


• Cyclosporine, digoxin, lithium, methotrexate, other NSAIDs (eg, ibuprofen), quinolones (eg, ciprofloxacin), or tenofovir because the risk of their side effects may be increased by Diclofenac/Misoprostol


• Angiotensin-converting enzyme (ACE) inhibitors (eg, captopril) or diuretics (eg, furosemide, hydrochlorothiazide) because their effectiveness may be decreased by Diclofenac/Misoprostol


• Medicines that may harm the liver (eg, acetaminophen, ketoconazole, isoniazid, certain medicines for HIV infection, certain antibiotics or seizure medicines) because the risk of liver side effects may be increased. Ask your doctor if you are unsure if any of your medicines might harm the liver

This may not be a complete list of all interactions that may occur. Ask your health care provider if Diclofenac/Misoprostol may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Diclofenac/Misoprostol:

Use Diclofenac/Misoprostol as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Diclofenac/Misoprostol comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get Diclofenac/Misoprostol refilled.


• Take Diclofenac/Misoprostol by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation.


• Do not take magnesium-containing antacids while taking Diclofenac/Misoprostol. If an antacid is needed, use one with calcium or aluminum.


• If you miss a dose of Diclofenac/Misoprostol, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Diclofenac/Misoprostol.

Important safety information:

• Diclofenac/Misoprostol may cause dizziness, drowsiness, or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use Diclofenac/Misoprostol with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.


• Diclofenac/Misoprostol may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to Diclofenac/Misoprostol. Use a sunscreen or wear protective clothing if you must be outside for more than a short time.


• Diabetes patients - Diclofenac/Misoprostol may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.


• Women who are able to become pregnant should use effective birth control while they are taking Diclofenac/Misoprostol. Talk with your doctor if you are unsure of effective birth control methods.


• Lab tests, including complete blood cell counts, blood electrolyte levels, and liver function, may be performed while you use Diclofenac/Misoprostol. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.


• Diclofenac/Misoprostol should not be used in CHILDREN; safety and effectiveness in children have not been confirmed.


• PREGNANCY and BREAST-FEEDING: Do not take Diclofenac/Misoprostol if you are pregnant. Avoid becoming pregnant while you are taking it. If you think you may be pregnant, contact your doctor right away. Diclofenac/Misoprostol is found in breast milk. Do not breast-feed while taking Diclofenac/Misoprostol.

Possible side effects of Diclofenac/Misoprostol:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Diarrhea; dizziness; drowsiness; gas; headache; indigestion; nausea; stomach pain or upset; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; unusual hoarseness); black, tarry stools; bleeding and ulcers in the stomach and intestines; chest pain; change in the amount of urine produced; dark urine; dizziness or blurred vision; fast or irregular heartbeat; loss of appetite; mental or mood changes; one-sided weakness; pale stools; persistent loss of appetite; red, swollen, blistered, or peeling skin; seizures; severe diarrhea or stomach pain; severe headache and stiff neck; severe nausea and vomiting; sudden or unexplained weight gain; swelling of the hands, legs, or feet; symptoms of infection (eg, chills, fever, sore throat); trouble breathing or shortness of breath; unusual bleeding or bruising; vaginal bleeding after menopause; vision, hearing, or speech problems; vomit that looks like coffee grounds; weakness, fatigue, or fainting; weight loss; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Diclofenac/Misoprostol side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include confusion; convulsions; diarrhea; difficulty breathing; dizziness; drowsiness; fever; light-headedness; nausea; sleepiness; stomach pain; tremor; unusually fast or slow heartbeat.

Proper storage of Diclofenac/Misoprostol:

Store Diclofenac/Misoprostol at 77 degrees F (25 degrees C) in a tightly closed container. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Diclofenac/Misoprostol out of the reach of children and away from pets.

General information:

• If you have any questions about Diclofenac/Misoprostol, please talk with your doctor, pharmacist, or other health care provider.


• Diclofenac/Misoprostol is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Diclofenac/Misoprostol. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Diclofenac/Misoprostol resources

• Diclofenac/Misoprostol Side Effects (in more detail)
• Diclofenac/Misoprostol Use in Pregnancy & Breastfeeding
• Diclofenac/Misoprostol Drug Interactions
• Diclofenac/Misoprostol Support Group
• 19 Reviews for Diclofenac/Misoprostol - Add your own review/rating

Compare Diclofenac/Misoprostol with other medications

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Papilock Mini

Papilock Mini may be available in the countries listed below.

Ingredient matches for Papilock Mini

Ciclosporin

Ciclosporin is reported as an ingredient of Papilock Mini in the following countries:

• Japan

International Drug Name Search

Allergodil

Allergodil may be available in the countries listed below.

Ingredient matches for Allergodil

Azelastine

Azelastine is reported as an ingredient of Allergodil in the following countries:

• Bulgaria


• Tunisia

Azelastine hydrochloride (a derivative of Azelastine) is reported as an ingredient of Allergodil in the following countries:

• Argentina


• Austria


• Belgium


• Cyprus


• Czech Republic


• Denmark


• Egypt


• Estonia


• France


• Georgia


• Germany


• Hungary


• Iraq


• Italy


• Jordan


• Kuwait


• Latvia


• Lebanon


• Libya


• Lithuania


• Luxembourg


• Netherlands


• Peru


• Poland


• Portugal


• Qatar


• Romania


• Russian Federation


• Saudi Arabia


• Slovakia


• Slovenia


• Sudan


• Switzerland


• Syria


• Turkey


• United Arab Emirates


• Venezuela


• Yemen

International Drug Name Search

Alphacaïne

Alphacaïne may be available in the countries listed below.

Ingredient matches for Alphacaïne

Articaine

Articaine hydrochloride (a derivative of Articaine) is reported as an ingredient of Alphacaïne in the following countries:

• France


• Switzerland

Epinephrine

Epinephrine hydrochloride (a derivative of Epinephrine) is reported as an ingredient of Alphacaïne in the following countries:

• France


• Switzerland

International Drug Name Search

Vetro Gen

In some countries, this medicine may only be approved for veterinary use.

Ingredient matches for Vetro Gen

Gentamicin

Gentamicin sulfate (a derivative of Gentamicin) is reported as an ingredient of Vetro Gen in the following countries:

• United States

International Drug Name Search